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Carthamus tinctorius L. (Safflower) of family Asteraceae is a medicinal plant with great potential. Its extract and oil has many therapeutic uses and having great pharmacological importance. Plant is mainly cultivated for its seeds, oil and flowers. It is to cure many day to day ailment, and has proved importance as purgative, analgesic, anti-inflammatory, antipyretic, menstrual problems, post-partum hemorrhage, osteoporosis, diabetes, hepatoprotection, cancer, fibrosis and antioxidant. Carthamine, hydroxyl safflower yellow-A, carthamidine, luteolin are the main phytoactive principles of this plant. This review highlights the pharmacological aspects of Carthamus tinctorius. Keywords- Carthamus tinctorius, Safflower, Pharmacology, future drug.
Diabetes is a serious metabolic disorder prevailing among people with ageing and sedentary lifestyle associated with rapidly growing urbanization and industrialization. Medicinal plants prescribed in thesaurus of Ayurveda and used by folklore have been a source of relief in controlling different types of diabetes all over the world. At the present time, the use of these herbal drugs is growing at high pace because of its cost effectiveness and free from the side effects over pharmaceutical hypoglycemic agents. The current review presents the profiles of approximately 35 plants having anti-diabetic activity and potential to reduce the oxidative stress, reported in the literature from 2005 to 2015. This review has been presented in such a fascinating manner which includes the plant along with its family, part used, phyto-constituents responsible for particular action in a tabulated form. Present study might provide a momentum to find newer antidiabetic entities.
Introduction: This paper provides significant information about traditional knowledge of medicinal plants to treat musculoskeletal disorders in Northern Pakistan. The study aimed to document data regarding traditional uses of plants in health-care practices among the rural communities of areas which may lead to natural drug discovery development. Methods: In total, 215 informants were interviewed using semi structured questionnaire. Documented ethno-medicinal data is analyzed using quantitative index of frequency citation (FC), relative frequency of citation (RFC), disease-consensus index (DCI), used value (UV), fidelity level (FL), jaccard index (JI), family important value (FIV), Relative popularity levely (RPL) and Rank priority order (ROP) and ethno-medicinal findings were compared with 25 previous published studies to report novel uses of plants against musculoskeletal disorder. Results: A total of 142 plants belonging to 69 families were reported with their medicinal usage to treat mus-culoskeletal disorders. The most dominant were herbs (57%), decoction was preferred method of utilization (35.2%) and leaves were the most used plant part (44.3%). The highest used category was recorded for rheumatism (44%) and the most used species were Celastrus paniculatus and Cyperus rotundus. RFC ranged from 0.098 to 0.586, Triticum aestivium with highest DCI (0.68) and Salvadoraceae was dominant family in terms of FIV (58.60). Conclusion: This study provides significant information about medicinal plants usage for musculoskeletal disorders among indigenous communities of Northern Pakistan. The baseline findings of this study might be useful in compiling data for future phytochemical and pharmacological screening of plants leading to natural drug discovery and development.
benthamscience.com
Medicinal Plants for the Management of Post Menopausal Osteoporosis: AArabian Journal of Chemistry
A quest for staunch effects of flavonoids: Utopian protection against hepatic ailments2012 •
Context: The use of medicinal plants from natural environment to alleviate suffering is perhaps as old in origin as man on this planet. All indigenous remedies, whether Eastern or Western have originated directly or indirectly from Traditional Medicines. The dominant Traditional System of Pakistan is the Unani System. Pakistan is located in South Asia and it is divided into nine major ecological zones, eighteen types of habitat along 6000 species of flowering plants. Only 12% of these species have multipurpose uses, such as with in nutrition, ornamental and local cottage industries. Flowers have always been natural reservoir of bioflavonoid, elements, vitamins and their reputed effects. For example Marshmallow flowers are used in intermittent fever, hematuria and constipation. The flowers are recommended for cough, boils and skin disorders. Dried Safflowers are used as cardiac and nervine tonic. Roselle calyx is used as a good source of Vitamin ?C?. Rose oil preparations helps to ease premenstrual tension. Alcoholic extract of Sesame flower demonstrate tumor growth. Objective: The objective of this paper is to review the literature regarding medicinal flower of Pakistan. Although, the value of medicinal flowers has been recognized worldwide, utilizing of species in Pakistan has not received much attention. Methods: The review has been compiled using references from Pub Med, Scientific Journals as well as classical literature from Bait al- Hikmah Library, Hamdard University. Results: The results showed that 145 Pakistani species distributed among 108 genera and 59 plant families were found to have medicinal flower values. Out of these the largest numbers of species were found in Asteraceae and Malvaceae (22 and 11 respectively) followed by Caesalpinaceae and Lamiaceae (7 and 7 species respectively) and Boraginaceae, Fabiaceae, Papilionaceae, Rosaceae (5 species respectively), Apocynaceae (4 species), Bignonaceae, Meliaceae, Mimoaceae, Solanaceae, Verbinaceae (3 species respectively).Other families contained only one and two species of medicinal flowers. Conclusion: A literature search was carried out to find which plants are used as flower therapeutic uses as well as biological activities. These could be used for edible food, medicinal preparations, cosmetic, and future utilization as alternative therapeutics. Keywords: Medicinal & Edible Flower, elements in flower, Tea, Cosmetic, Scent, Flowers availability in Pakistan, Hamdard University.
Journal of Microbiology, Biotechnology and Food Sciences
POLYPHENOLIC AND FLAVONOIDS CONTENT, HPLC PROFILING AND ANTIOXIDANT ACTIVITY OF SOME MEDICINAL PLANTS WITH PANCREATIC HISTOLOGICAL STUDY IN ALLOXAN-INDUCED DIABETIC RATS MODEL2020 •
Background: Medicinal plants are considered a very important source of natural crude materials which are used in pharmaceutical industries. Nowadays, many investigators focused their studies for medicinal plants in order to extract components which have effects as antibacterial and antioxidant activities, also, some diseases such as diabetes, cardiovascular, diarrhea, antitumor and anticancer, etc. Our study focused in the biochemical characterization of Portulaca oleracea and Carthamus tinctorius to study their antidiabetic activity in alloxan induced diabetes in rats. Methods: Extracts from Portulaca oleracea leaves and Carthamus tinctorius flowers were prepared then their total phenolic and flavonoid content and identification by HPLC technique were analyzed. Moreover, the antioxidant activity using (FRAP and DPPH radical) were determined. Randomly allocated male white Wistar rats into four groups of five each: non-diabetic control; diabetic control; diabetic treated with Carthamus tinctorius extract (200 mg kg-1 BW); diabetic treated with Portulaca oleracea extract daily (250 mg/kg), then pancreatic tissues were collected and routinely processed for histopathological examination. Results indicate that methanolic extract of Portulaca oleracea leaves had the largest total polyphenols and flavonoids content, which were 129.03 mg GAE/g and 22.55 mg QE/g, followed by Carthamus tinctorius flowers methanolic extract, which were 102.44 mg GAE/g and 13.94 mg QE/g, respectively. Identification of total polyphenols and flavonoids were estimated by HPLC. The methanolic extract of Portulaca oleracea leaves, had the highest reducing power which was 1.921 at the concentrations of 80 mg/ml. followed by Carthamus tinctorius flowers extract. Also, by using (DPPH +), the highest antioxidants activity was for Portulaca oleracea leaves extract. Microscopic examination of pancreatic tissues from rats treated with Portulaca oleracea and Carthamus tinctorius revealed their anti-diabetic activity with improved histological tissue changes compared with alloxan induced diabetic group. Moreover, antidiabetic activity of Portulaca oleracea recorded more histological improvement than that of Carthamus tinctorius compared with the control non diabetic group.
Journal of Agricultural and Food Chemistry
Variation in Phenolic Composition and Antioxidant Activity during Flower Development of Safflower (Carthamus tinctorius L.)2011 •
Biomedicine & Pharmacotherapy
The mechanistic insight of polyphenols in calcium oxalate urolithiasis mitigation2018 •
International Journal of Drug Development & Research
Pharmacological Screening, Ayurvedic values and Commercial Utility of Aegle MarmelosCARTHAMUS OXYCANTHA
POTENTIAL BIOACTIVE PHYTOCONSTITUENTS IN CARTHAMUS OXYCANTHA M. BIEB. ROOT2018 •
Acta Physiologiae Plantarum
Effect of salinity on plant growth and biological activities of Carthamus tinctorius L. extracts at two flowering stages2014 •
2014 •
Evidence-Based Complementary and Alternative Medicine
Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic Asthma2011 •
Pharmacologyonline
STUDY OF ANTIOXIDANT POTENTIAL, AND QUANTIFICATION OF MAJOR POLYPHENOLS IN LEONURUS SIBIRICUS L. LEAVES USING HPLC2017 •
British Journal of Nutrition
Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells2009 •